The reason why many usb serial adapters does not work with windows 10 is because these adapters are made with a low cost processor chip which complies only with the minimum requirements or less.
Usb to serial adapter windows 10 compatible.
Why many low cost usb serial adapter cables does not work with windows 10.
It defines windows runtime classes that can use to communicate with a usb cdc device through a serial port or some abstraction of a serial port.
Click the power management tab.
Expand universal serial bus controllers by clicking the arrow to the left of it.
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Right click the first usb root hub device and select properties.
To fix windows 64 bit os including prolific usb to serial adapter follow through these steps.
Download pl2303 64bit installer exe and save.
Click ok to apply the setting.
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Follow the prompt by plugging in one usb to serial adapter the click on continue.
Clear the box next to allow the computer to turn off this device to save power.